
The pan-European STOXX 600 index was down 0.8% at 542.38 points by 0710 GMT. It had snapped a five-session losing streak on Monday.
The Israel-Iran conflict extended to a fifth straight day on Tuesday, with U.S. President Donald Trump urging Iranians to evacuate Tehran, citing what he said was the country's rejection of a deal to curb nuclear weapons development.
Trump had departed early from the Group of Seven summit in Canada but clarified that this it has "nothing to do" with working on a ceasefire leaving investors with no clarity on the conflict.
Oil prices ticked higher following the heightened tensions, before retreating. Energy shares outperformed peers, up 0.3%.
All other sectors were in the red, with telecom firms leading declines at 1.4%.
Among stocks, London's Ashtead was among the top percentage gainers despite forecasting a slowdown in rental revenue growth.
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